Center for Musculoskeletal Research

Johns Hopkins University School of Medicine

  • Pan D, Benkato KG, Han X, Kumar V, Wan M, Zheng J, Cao X. Endplate senescent osteoclasts induce sensory innervation and spine pain. eLife (in press). A press release for this paper on our website here: https://elifesciences.org/for-the-press/828e9511/drug-that-kills-off-sleeping-bone-cells-could-treat-lower-back-pain
  • Wang J, Fang CL, Noller K, Wei Z, Liu G, Shen K, Song K, Cao X, Wan M. Bone-derived PDGF-BB drives brain vascular calcification in male mice. J Clin Invest. 2023 Dec 1;133(23):e168447. doi: 10.1172/JCI168447. PMID: 37815871; PMCID: PMC10688993.
  • Guo Q, Chen N, Patel K, Wan M, Zheng J, Cao X. Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism. Adv Sci (Weinh). 2023 Oct 25:e2305042. doi: 10.1002/advs.202305042. Epub ahead of print. PMID: 37880864.
  • Ling Z, Crane J, Hu H, Chen Y, Wan M, Ni S, Demehri S, Mohajer B, Peng X, Zou X, Cao X. Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration. Sci Transl Med. 2023 Nov 15;15(722):eadg8982. doi: 10.1126/scitranslmed.adg8982. Epub 2023 Nov 15. PMID: 37967203.
  • Wu Q, Cui X, Guan LC, Zhang C, Liu J, Ford NC, He S, Chen X, Cao X, Zang L, Guan Y. Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy. J Orthop Translat. 2023 Sep 30;42:147-159. doi: 10.1016/j.jot.2023.07.003. PMID: 37823035; PMCID: PMC10562770.
  • Yang, Z., Wang, J.,Yin, B.,Liu, W.,Yin, D.,Shen, J.,Wang, W.,Li, L.,Guo, X.,Stimuli-Induced Subconformation Transformation of the PSI-LHCI Protein at Single-Molecule Resolution.Adv. Sci.2023, 2205945.https://doi.org/10.1002/advs.202205945.
  • Guo, Q., Chen, N.,Qian, C.,Qi, C.,Noller, K.,Wan, M.,Liu, X.,Zhang, W.,Cahan, P.,Cao, X.,Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation.Adv. Sci.2023, 2207602.https://doi.org/10.1002/advs.202207602.
  • Qiaoyue Guo, Ningrong Chen, Cheng Qian, Cheng Qi, Kathleen Noller, Mei Wan, Xiaonan Liu, Weixin Zhang, Patrick Cahan, and Xu Cao Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation. 2023,Advanced Sciencepublished online. https://doi.org/10.1002/advs.202207602.
  • Li Y, Wang X, Hu B, Sun Q, Wan M, Carr A, Liu S, Cao X. Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion. Bone Res. 2023 May 8;11(1):24. doi: 10.1038/s41413-023-00252-1. PMID: 37156778; PMCID: PMC10167238.
  • Zhang W, Noller K, Crane J, Wan M, Wu X, Cahan P,Cao X.RANK+TLR2+myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis.Elife. 2023 May 19;12: e85553. doi: 10.7554/eLife.85553.PMID:37204303. This article is accompanied with a commentary Article: Unraveling the mechanisms behind joint damage: A subtype of myeloid monocyte mediates the transition from autoimmunity to joint destruction in rheumatoid arthritis. eLife 2023;12: e89778. DOI:https://doi.org/10.7554/eLife.89778.
  • Mo KC, Gupta A, MovsikJ, CovarrubiusO, Greenberg M, Riley LH 3rd, Kebaish KM, Neuman BJ, Skolasky RL. Pain Self-Efficacy (PSEQ) score of <22 is associated with daily opioid use, back pain, disability, and PROMIS scores in patients presenting for spine surgery. Spine J. 2023 May;23(5):723-730. doi: 10.1016/j.spinee.2022.12.015. PMID: 37100496; PMCID: PMC10154031.
  • Liu X, Gu Y, Kumar S, Amin S, Guo Q, Wang J, Fang CL, Cao X, Wan M. Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Cell Metab. 2023 Apr 4;35(4):667-684.e6. doi: 10.1016/j.cmet.2023.03.005. PMID: 37019080; PMCID: PMC10127143.
  • Wen Z, Xia G, Liang C, Wang X, Huang J, Zhang L, Shan D, Wu S, Cao X. Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis. Antioxid Redox Signal. 2023 Mar 2. doi: 10.1089/ars.2022.0141. Epub ahead of print. PMID: 36601724.
  • Lv X, Gao F, Cao X. Skeletal interoception in bone homeostasis and pain. Cell Metab. 2022 Dec 6;34(12):1914-1931. doi: 10.1016/j.cmet.2022.09.025. Epub 2022 Oct 17. PMID: 36257317; PMCID: PMC9742337.
  • Su W, Liu G, Mohajer B, Wang J, Shen A, Zhang W, Liu B, Guermazi A, Gao P, Cao X, Demehri S, Wan M. Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2. Elife. 2022 Jul 26;11:e79773. doi: 10.7554/eLife.79773. PMID: 35881544; PMCID: PMC9365389.
  • Zhen, G., Fu, Y., Zhang, C. et al.Mechanisms of bone pain: Progress in research from bench to bedside.Bone Res10, 44 (2022). https://doi.org/10.1038/s41413-022-00217
  • Taylor JL, Regier NG, Li Q, Liu M, SzantonSL, Skolasky RL. The impact of low back pain and vigorous activity on mental and physical health outcomes in older adults with arthritis. Front Pain Res (Lausanne). 2022 Jul 22; 3:886985. doi: 10.3389/fpain.2022.886985. PMID: 35935669; PMCID: PMC9355128.
  • MarracheM, Prasad N, Margalit A, Nayar SK, Best MJ, Fritz JM, Skolasky RL. Initial presentation for acute low back pain: is early physical therapy associated with healthcare utilizationand spending? A retrospective review of a National Database. BMC Health Serv Res. 2022 Jul 2;22(1):851. doi: 10.1186/s12913-022-08255-0. PMID: 35778738; PMCID: PMC9250203.
  • Zhang C, Hu M, Wang X, Cui X, Liu J, Huang Q, Cao X, Zhou F, Qian J, He S, Guan Y. scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons ofPirtEGFPfmice in neuropathic pain condition. eLife 2022;11:e76063. DOI:https://doi.org/10.7554/eLife.76063
  • Bronheim RS, Kebaish KM, Jain A, Neuman BJ, Skolasky RL. Worsening pain and quality of life for spine surgery patients during the COVID-19 pandemic: Roles of psychological distress and patient activation. N Am Spine Soc J. 2022 Mar;9:100103. doi: 10.1016/
  • Dou C, Zhen G, Dan Y, Wan M, Limjunyawong N, Cao X. Sialylation of TLR2 initiates osteoclast fusion. Bone Res. 2022 Mar 2;10(1):24. doi: 10.1038/s41413-022-00186-0.PMID: 35232979
  • McNeely EL, Zhang B, Neuman BJ, Skolasky RL. Estimating measurement error of the Oswestry Disability Index with missing data. Spine J. 2022 Feb 1:S1529-9430(22)00036-5. doi: 10.1016/j.spinee.2022.01.013. Epub ahead of print. PMID: 35121153.
  • Wang X, Liu S, Yu T, An S, Deng R, Tan X, Crane J, Zhang W, Pan D, Wan M, Carr A, Cao X. Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy. Adv Sci (Weinh). 2022 Feb 15:e2104469. doi: 10.1002/advs.202104469. Online ahead of print.PMI
  • Qiao W, Pan D, Zheng Y, Wu S, Liu X, Chen Z, Wan M, Feng S, Cheung KMC, Yeung KWK, Cao X. Divalent Metal Cations Stimulate Skeleton Interoception for New Bone Formation in Mouse Injury Models. Nat Commun. 2022 Jan 27;13(1):535. doi: 10.1038/s41467-022-282
  • Deng R, Li C, Wang X, Chang L, Ni S, Zhang W, Xue P, Pan D, Wan M, Deng L, Cao X. Periosteal CD68+ F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1. Adv Sci (Weinh). 2022 Jan;9(3):e2103343. doi: 10.1002/advs.202103343. Epub 2021 Dec 2. PMID: 34854257; PMCID: PMC8787385.
  • Zhen G, Dan Y, Wang R, Dou C, Guo Q, Zarr M, Liu LN, Chen L, Deng R, Li Y, Shao Z, Cao X. An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion. Bone Res. 2021 Nov 1;9(1):47.
  • Santhanam L, Liu G, Jandu S, Su W, Wodu BP, Savage W, Poe A, Liu X, Alexander LM, Cao X,WanM.Skeleton-secreted PDGF-BB mediates arterial stiffening.J Clin Invest. 2021 Oct 15;131(20):e147116. doi: 10.1172/JCI147116.
  • Wan M, Gray-Gaillard EF, Elisseeff JH. Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration. Bone Res. 2021 Sep 10;9(1):41. doi: 10.1038/s41413-021-00164-y.PMID: 34508069
  • Xiao Lv,Feng Gao,Tuo Peter Li,Peng Xue,Xiao Wang,Mei Wan,Bo Hu,Hao Chen,Amit Jain,Zengwu Shao,Xu Cao.Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY.Elife.2021 Sep 1;10:e70324. doi: 10.7554/eL
  • Xue P, Wang S, Lyu X, Wan M, Li X, Ma L, Ford NC, Li Y, Guan Y, Ding W, Cao X. PGE2/EP4 Skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib. Bone Res. 2021 Aug 2;9(1):36. doi: 10.1038/s41413-021-0015
  • Mohajer B, Kwee RM, Guermazi A, Berenbaum F, Wan M, Zhen G, Cao X, Haugen IK, Demehri S. Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative. J Rheumatol. 2021 Jun
  • Yu T, Zhang J, Zhu W, Wang X, Bai Y, Feng B, Zhuang Q, Han C, Wang S, Hu Q, An S, Wan M, Dong S, Xu J, Weng X, Cao X. Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification. Bone Res. 2021 Mar 17;9(1):19. doi: 10.10
  • Zhen G, Guo Q, Li Y, et al. Mechanical stress determines the configuration of TGFβactivation in articular cartilage. Nat Commun. Mar 17 2021;12(1):1706. doi:10.1038/s41467-021-21948-0
  • Liu X, Chai Y, Liu G, et al. Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. Nat Commun. Mar 23 2021;12(1):1832. doi:10.1038/s41467-021-22131-1
  • Sun Q, Zhen G, Li TP, Guo Q, Li Y, Su W, Xue P, Wang X, Wan M, Guan Y, Dong X, Li S, Cai M, Cao X. Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice. Elife. 2021 Mar 1;10:e66532. doi: 10.7554/eLife.66532. PMID: 33646122; PMCID: PMC8012060.